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Fats, Friends or Foes: Investigating the Role of Short- and Medium-Chain Fatty Acids in Alzheimer's Disease.
Ameen AO, Freude K, Aldana BI. Ameen AO, et al. Biomedicines. 2022 Nov 1;10(11):2778. doi: 10.3390/biomedicines10112778. Biomedicines. 2022. PMID: 36359298 Free PMC article. Review.
Characterising Alzheimer's disease (AD) as a metabolic disorder of the brain is gaining acceptance based on the pathophysiological commonalities between AD and major metabolic disorders. ...
Characterising Alzheimer's disease (AD) as a metabolic disorder of the brain is gaining acceptance based on the pathoph …
Comprehensive Analysis of the 5xFAD Mouse Model of Alzheimer's Disease Using dMRI, Immunohistochemistry, and Neuronal and Glial Functional Metabolic Mapping.
Westi EW, Molhemi S, Hansen CT, Skoven CS, Knopper RW, Ahmad DA, Rindshøj MB, Ameen AO, Hansen B, Kohlmeier KA, Aldana BI. Westi EW, et al. Biomolecules. 2024 Oct 13;14(10):1294. doi: 10.3390/biom14101294. Biomolecules. 2024. PMID: 39456227 Free PMC article.
Alzheimer's disease (AD) is characterized by complex interactions between neuropathological markers, metabolic dysregulation, and structural brain changes. ...
Alzheimer's disease (AD) is characterized by complex interactions between neuropathological markers, metabolic dysregul
The SORL1 p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer's disease.
Jensen AMG, Raska J, Fojtik P, Monti G, Lunding M, Bartova S, Pospisilova V, van der Lee SJ, Van Dongen J, Bossaerts L, Van Broeckhoven C, Dols-Icardo O, Lléo A, Bellini S, Ghidoni R, Hulsman M, Petsko GA, Sleegers K, Bohaciakova D, Holstege H, Andersen OM. Jensen AMG, et al. Proc Natl Acad Sci U S A. 2024 Sep 10;121(37):e2408262121. doi: 10.1073/pnas.2408262121. Epub 2024 Sep 3. Proc Natl Acad Sci U S A. 2024. PMID: 39226352
Truncating genetic variants of SORL1, encoding the endosome recycling receptor SORLA, have been accepted as causal of Alzheimer's disease (AD). However, most genetic variants observed in SORL1 are missense variants, for which it is complicated to determine th …
Truncating genetic variants of SORL1, encoding the endosome recycling receptor SORLA, have been accepted as causal of Alzheimer's