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Adrenomedullin haploinsufficiency predisposes to secondary lymphedema.
Nikitenko LL, Shimosawa T, Henderson S, Mäkinen T, Shimosawa H, Qureshi U, Pedley RB, Rees MC, Fujita T, Boshoff C. Nikitenko LL, et al. J Invest Dermatol. 2013 Jul;133(7):1768-76. doi: 10.1038/jid.2013.47. Epub 2013 Jan 30. J Invest Dermatol. 2013. PMID: 23364478 Free PMC article.
The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis.
Nikitenko LL, Leek R, Henderson S, Pillay N, Turley H, Generali D, Gunningham S, Morrin HR, Pellagatti A, Rees MC, Harris AL, Fox SB. Nikitenko LL, et al. Clin Cancer Res. 2013 Oct 15;19(20):5740-8. doi: 10.1158/1078-0432.CCR-13-1712. Epub 2013 Aug 22. Clin Cancer Res. 2013. PMID: 23969937 Free PMC article.