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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.
Podsypanina K, Lee RT, Politis C, Hennessy I, Crane A, Puc J, Neshat M, Wang H, Yang L, Gibbons J, Frost P, Dreisbach V, Blenis J, Gaciong Z, Fisher P, Sawyers C, Hedrick-Ellenson L, Parsons R. Podsypanina K, et al. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10320-5. doi: 10.1073/pnas.171060098. Epub 2001 Aug 14. Proc Natl Acad Sci U S A. 2001. PMID: 11504907 Free PMC article.