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Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin, compared with regular/NPH insulin in female patients with type 1 diabetes.
Griffen SC, Oostema K, Stanhope KL, Graham J, Styne DM, Glaser N, Cummings DE, Connors MH, Havel PJ. Griffen SC, et al. J Clin Endocrinol Metab. 2006 Feb;91(2):485-91. doi: 10.1210/jc.2005-1338. Epub 2005 Nov 29. J Clin Endocrinol Metab. 2006. PMID: 16317063 Clinical Trial.