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Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding.
Leinninger GM, Jo YH, Leshan RL, Louis GW, Yang H, Barrera JG, Wilson H, Opland DM, Faouzi MA, Gong Y, Jones JC, Rhodes CJ, Chua S Jr, Diano S, Horvath TL, Seeley RJ, Becker JB, Münzberg H, Myers MG Jr. Leinninger GM, et al. Cell Metab. 2009 Aug;10(2):89-98. doi: 10.1016/j.cmet.2009.06.011. Cell Metab. 2009. PMID: 19656487 Free PMC article.
Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance.
Flak JN, Patterson CM, Garfield AS, D'Agostino G, Goforth PB, Sutton AK, Malec PA, Wong JT, Germani M, Jones JC, Rajala M, Satin L, Rhodes CJ, Olson DP, Kennedy RT, Heisler LK, Myers MG Jr. Flak JN, et al. Nat Neurosci. 2014 Dec;17(12):1744-1750. doi: 10.1038/nn.3861. Epub 2014 Nov 10. Nat Neurosci. 2014. PMID: 25383904 Free PMC article.
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