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Glucocerebrosidase 2 gene deletion rescues type 1 Gaucher disease.
Mistry PK, Liu J, Sun L, Chuang WL, Yuen T, Yang R, Lu P, Zhang K, Li J, Keutzer J, Stachnik A, Mennone A, Boyer JL, Jain D, Brady RO, New MI, Zaidi M. Mistry PK, et al. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4934-9. doi: 10.1073/pnas.1400768111. Epub 2014 Mar 17. Proc Natl Acad Sci U S A. 2014. PMID: 24639522 Free PMC article.
Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage.
Mistry PK, Liu J, Yang M, Nottoli T, McGrath J, Jain D, Zhang K, Keutzer J, Chuang WL, Mehal WZ, Zhao H, Lin A, Mane S, Liu X, Peng YZ, Li JH, Agrawal M, Zhu LL, Blair HC, Robinson LJ, Iqbal J, Sun L, Zaidi M. Mistry PK, et al. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19473-8. doi: 10.1073/pnas.1003308107. Epub 2010 Oct 20. Proc Natl Acad Sci U S A. 2010. PMID: 20962279 Free PMC article.
Further evidence for direct pro-resorptive actions of FSH.
Sun L, Zhang Z, Zhu LL, Peng Y, Liu X, Li J, Agrawal M, Robinson LJ, Iqbal J, Blair HC, Zaidi M. Sun L, et al. Biochem Biophys Res Commun. 2010 Mar 26;394(1):6-11. doi: 10.1016/j.bbrc.2010.02.113. Epub 2010 Feb 19. Biochem Biophys Res Commun. 2010. PMID: 20171951 Free PMC article.