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MAIT cells are imprinted by the microbiota in early life and promote tissue repair.
Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y. Constantinides MG, et al. Science. 2019 Oct 25;366(6464):eaax6624. doi: 10.1126/science.aax6624. Science. 2019. PMID: 31649166 Free PMC article.
Early life host-microbe interactions in skin.
Dwyer LR, Scharschmidt TC. Dwyer LR, et al. Cell Host Microbe. 2022 May 11;30(5):684-695. doi: 10.1016/j.chom.2022.02.016. Cell Host Microbe. 2022. PMID: 35550671 Free PMC article. Review.
Baby's skin bacteria: first impressions are long-lasting.
Dhariwala MO, Scharschmidt TC. Dhariwala MO, et al. Trends Immunol. 2021 Dec;42(12):1088-1099. doi: 10.1016/j.it.2021.10.005. Epub 2021 Nov 4. Trends Immunol. 2021. PMID: 34743922 Free PMC article. Review.
Intestinal inflammation alters the antigen-specific immune response to a skin commensal.
Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC. Merana GR, et al. Cell Rep. 2022 May 31;39(9):110891. doi: 10.1016/j.celrep.2022.110891. Cell Rep. 2022. PMID: 35649365 Free PMC article.
Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.
Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD. Lowe MM, et al. JCI Insight. 2019 Dec 19;4(24):e129756. doi: 10.1172/jci.insight.129756. JCI Insight. 2019. PMID: 31852848 Free PMC article.