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Page 1
GOLPH3 links the Golgi, DNA damage, and cancer.
Buschman MD, Rahajeng J, Field SJ. Buschman MD, et al. Cancer Res. 2015 Feb 15;75(4):624-7. doi: 10.1158/0008-5472.CAN-14-3081. Epub 2015 Jan 29. Cancer Res. 2015. PMID: 25634214 Free PMC article. Review.
DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3.
Farber-Katz SE, Dippold HC, Buschman MD, Peterman MC, Xing M, Noakes CJ, Tat J, Ng MM, Rahajeng J, Cowan DM, Fuchs GJ, Zhou H, Field SJ. Farber-Katz SE, et al. Cell. 2014 Jan 30;156(3):413-27. doi: 10.1016/j.cell.2013.12.023. Cell. 2014. PMID: 24485452 Free PMC article.
GOLPH3L antagonizes GOLPH3 to determine Golgi morphology.
Ng MM, Dippold HC, Buschman MD, Noakes CJ, Field SJ. Ng MM, et al. Mol Biol Cell. 2013 Mar;24(6):796-808. doi: 10.1091/mbc.E12-07-0525. Epub 2013 Jan 23. Mol Biol Cell. 2013. PMID: 23345592 Free PMC article.
Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies.
Bielas SL, Silhavy JL, Brancati F, Kisseleva MV, Al-Gazali L, Sztriha L, Bayoumi RA, Zaki MS, Abdel-Aleem A, Rosti RO, Kayserili H, Swistun D, Scott LC, Bertini E, Boltshauser E, Fazzi E, Travaglini L, Field SJ, Gayral S, Jacoby M, Schurmans S, Dallapiccola B, Majerus PW, Valente EM, Gleeson JG. Bielas SL, et al. Nat Genet. 2009 Sep;41(9):1032-6. doi: 10.1038/ng.423. Epub 2009 Aug 9. Nat Genet. 2009. PMID: 19668216 Free PMC article.
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.
Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. Schmid MC, et al. Cancer Cell. 2011 Jun 14;19(6):715-27. doi: 10.1016/j.ccr.2011.04.016. Cancer Cell. 2011. PMID: 21665146 Free PMC article.