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Arginase 1 is a key driver of immune suppression in pancreatic cancer.
Menjivar RE, Nwosu ZC, Du W, Donahue KL, Hong HS, Espinoza C, Brown K, Velez-Delgado A, Yan W, Lima F, Bischoff A, Kadiyala P, Salas-Escabillas D, Crawford HC, Bednar F, Carpenter E, Zhang Y, Halbrook CJ, Lyssiotis CA, Pasca di Magliano M. Menjivar RE, et al. Elife. 2023 Feb 2;12:e80721. doi: 10.7554/eLife.80721. Elife. 2023. PMID: 36727849 Free PMC article.
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth.
Donahue KL, Watkoske HR, Kadiyala P, Du W, Brown K, Scales MK, Elhossiny AM, Espinoza CE, Lasse Opsahl EL, Griffith BD, Wen Y, Sun L, Velez-Delgado A, Renollet NM, Morales J, Nedzesky NM, Baliira RK, Menjivar RE, Medina-Cabrera PI, Rao A, Allen B, Shi J, Frankel TL, Carpenter ES, Bednar F, Zhang Y, Pasca di Magliano M. Donahue KL, et al. Cancer Discov. 2024 Oct 4;14(10):1964-1989. doi: 10.1158/2159-8290.CD-24-0100. Cancer Discov. 2024. PMID: 38958646 Free PMC article.
Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer.
Scales MK, Velez-Delgado A, Steele NG, Schrader HE, Stabnick AM, Yan W, Mercado Soto NM, Nwosu ZC, Johnson C, Zhang Y, Salas-Escabillas DJ, Menjivar RE, Maurer HC, Crawford HC, Bednar F, Olive KP, Pasca di Magliano M, Allen BL. Scales MK, et al. PLoS Genet. 2022 Jul 22;18(7):e1010315. doi: 10.1371/journal.pgen.1010315. eCollection 2022 Jul. PLoS Genet. 2022. PMID: 35867772 Free PMC article.
Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer.
Yan W, Steele NG, Kemp SB, Menjivar RE, Du W, Carpenter ES, Donahue KL, Brown KL, Irizarry-Negron V, Yang S, Burns WR 3rd, Zhang Y, di Magliano MP, Bednar F. Yan W, et al. bioRxiv [Preprint]. 2023 Jan 13:2023.01.11.523584. doi: 10.1101/2023.01.11.523584. bioRxiv. 2023. Update in: Cancer Immunol Res. 2024 Jan 3;12(1):91-106. doi: 10.1158/2326-6066.CIR-23-0037 PMID: 36711890 Free PMC article. Updated. Preprint.