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A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo.
Pöhlmann S, Münch J, Aziz S, Reeves JD, Otto C, Leslie GJ, Hofmann H, Puffer BA, Baribaud F, Marzi A, Gramberg T, Chen Z, Stolte N, Haaft PT, Heeney JL, Stahl-Hennig C, Mätz-Rensing K, Schneider T, Doms RW, Kirchhoff F. Pöhlmann S, et al. Virology. 2007 Apr 10;360(2):275-85. doi: 10.1016/j.virol.2006.10.020. Epub 2006 Nov 28. Virology. 2007. PMID: 17126374 Free article.