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Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2.
Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K; QCRG Structural Biology Consortium; Zhou XX, Leung KK, Wells JA. Bracken CJ, et al. Nat Chem Biol. 2021 Jan;17(1):113-121. doi: 10.1038/s41589-020-00679-1. Epub 2020 Oct 20. Nat Chem Biol. 2021. PMID: 33082574 Free PMC article.
Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer.
Moroz A, Wang YH, Sharib JM, Wei J, Zhao N, Huang Y, Chen Z, Martinko AJ, Zhuo J, Lim SA, Zhang LH, Seo Y, Carlin S, Leung KK, Collisson EA, Kirkwood KS, Wells JA, Evans MJ. Moroz A, et al. Clin Cancer Res. 2020 Jul 15;26(14):3608-3615. doi: 10.1158/1078-0432.CCR-20-0268. Epub 2020 Apr 27. Clin Cancer Res. 2020. PMID: 32341034 Free PMC article.
Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike.
Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K; QCRG Structural Biology Consortium; Zhou XX, Leung KK, Wells JA. Bracken CJ, et al. bioRxiv [Preprint]. 2020 Aug 10:2020.08.08.242511. doi: 10.1101/2020.08.08.242511. bioRxiv. 2020. Update in: Nat Chem Biol. 2021 Jan;17(1):113-121. doi: 10.1038/s41589-020-00679-1 PMID: 32817948 Free PMC article. Updated. Preprint.