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Chemoinformatic-Guided Engineering of Polyketide Synthases.
Zargar A, Lal R, Valencia L, Wang J, Backman TWH, Cruz-Morales P, Kothari A, Werts M, Wong AR, Bailey CB, Loubat A, Liu Y, Chen Y, Chang S, Benites VT, Hernández AC, Barajas JF, Thompson MG, Barcelos C, Anayah R, Martin HG, Mukhopadhyay A, Petzold CJ, Baidoo EEK, Katz L, Keasling JD. Zargar A, et al. J Am Chem Soc. 2020 Jun 3;142(22):9896-9901. doi: 10.1021/jacs.0c02549. Epub 2020 May 18. J Am Chem Soc. 2020. PMID: 32412752
A bimodular PKS platform that expands the biological design space.
Zargar A, Valencia L, Wang J, Lal R, Chang S, Werts M, Wong AR, Hernández AC, Benites V, Baidoo EEK, Katz L, Keasling JD. Zargar A, et al. Metab Eng. 2020 Sep;61:389-396. doi: 10.1016/j.ymben.2020.07.001. Epub 2020 Aug 6. Metab Eng. 2020. PMID: 32771628