Whole-exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemia

Leukemia. 2014 Apr;28(4):945-8. doi: 10.1038/leu.2013.314. Epub 2013 Oct 25.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Chromosomes, Human, Pair 1*
  • Chromosomes, Human, Pair 22*
  • DNA-Binding Proteins / genetics
  • Exome*
  • Humans
  • Leukemia, Megakaryoblastic, Acute / drug therapy
  • Leukemia, Megakaryoblastic, Acute / genetics*
  • Male
  • Matrix Metalloproteinase 8 / genetics*
  • Mutation*
  • Oncogene Proteins, Fusion / genetics
  • Polymorphism, Single Nucleotide
  • RNA-Binding Proteins / genetics
  • Trans-Activators
  • Translocation, Genetic*

Substances

  • DNA-Binding Proteins
  • MRTFA protein, human
  • Oncogene Proteins, Fusion
  • RBM15 protein, human
  • RNA-Binding Proteins
  • Trans-Activators
  • MMP8 protein, human
  • Matrix Metalloproteinase 8