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Page 1
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.
Giampazolias E, Schulz O, Lim KHJ, Rogers NC, Chakravarty P, Srinivasan N, Gordon O, Cardoso A, Buck MD, Poirier EZ, Canton J, Zelenay S, Sammicheli S, Moncaut N, Varsani-Brown S, Rosewell I, Reis e Sousa C. Giampazolias E, et al. Cell. 2021 Jul 22;184(15):4016-4031.e22. doi: 10.1016/j.cell.2021.05.021. Epub 2021 Jun 2. Cell. 2021. PMID: 34081922 Free PMC article.
Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.
Bonavita E, Bromley CP, Jonsson G, Pelly VS, Sahoo S, Walwyn-Brown K, Mensurado S, Moeini A, Flanagan E, Bell CR, Chiang SC, Chikkanna-Gowda CP, Rogers N, Silva-Santos B, Jaillon S, Mantovani A, Reis e Sousa C, Guerra N, Davis DM, Zelenay S. Bonavita E, et al. Immunity. 2020 Dec 15;53(6):1215-1229.e8. doi: 10.1016/j.immuni.2020.10.020. Epub 2020 Nov 20. Immunity. 2020. PMID: 33220234 Free PMC article.
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens.
Canton J, Blees H, Henry CM, Buck MD, Schulz O, Rogers NC, Childs E, Zelenay S, Rhys H, Domart MC, Collinson L, Alloatti A, Ellison CJ, Amigorena S, Papayannopoulos V, Thomas DC, Randow F, Reis e Sousa C. Canton J, et al. Nat Immunol. 2021 Feb;22(2):140-153. doi: 10.1038/s41590-020-00824-x. Epub 2020 Dec 21. Nat Immunol. 2021. PMID: 33349708 Free PMC article.
Loss of secreted gelsolin enhances response to anticancer therapies.
Lim KHJ, Giampazolias E, Schulz O, Rogers NC, Wilkins A, Sahai E, Strid J, Reis e Sousa C. Lim KHJ, et al. J Immunother Cancer. 2022 Sep;10(9):e005245. doi: 10.1136/jitc-2022-005245. J Immunother Cancer. 2022. PMID: 36162919 Free PMC article.
Sensing infection and tissue damage.
Reis e Sousa C. Reis e Sousa C. EMBO Mol Med. 2017 Mar;9(3):285-288. doi: 10.15252/emmm.201607227. EMBO Mol Med. 2017. PMID: 28119319 Free PMC article.
27 results