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A secreted tyrosine kinase acts in the extracellular environment.
Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE Jr, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M. Bordoli MR, et al. Cell. 2014 Aug 28;158(5):1033-1044. doi: 10.1016/j.cell.2014.06.048. Cell. 2014. PMID: 25171405 Free PMC article.
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, Kim YJ, Lee HK, Cortese JF, Wirth DF, Dignam JD, Rao A, Yeo CY, Mazitschek R, Whitman M. Keller TL, et al. Nat Chem Biol. 2012 Feb 12;8(3):311-7. doi: 10.1038/nchembio.790. Nat Chem Biol. 2012. PMID: 22327401 Free PMC article.