HL085357/HL/NHLBI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2008	3
2009	3
2011	3
2012	2
2013	1
2020	1
2021	1
2024	0

1

Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair.

Shanmukhappa K, Matte U, Degen JL, Bezerra JA. Shanmukhappa K, et al. J Biol Chem. 2009 May 8;284(19):12917-23. doi: 10.1074/jbc.M807313200. Epub 2009 Mar 13. J Biol Chem. 2009. PMID: 19286661 Free PMC article.

2

Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway.

Vidal B, Serrano AL, Tjwa M, Suelves M, Ardite E, De Mori R, Baeza-Raja B, Martínez de Lagrán M, Lafuste P, Ruiz-Bonilla V, Jardí M, Gherardi R, Christov C, Dierssen M, Carmeliet P, Degen JL, Dewerchin M, Muñoz-Cánoves P. Vidal B, et al. Genes Dev. 2008 Jul 1;22(13):1747-52. doi: 10.1101/gad.465908. Genes Dev. 2008. PMID: 18593877 Free PMC article.

3

Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain.

Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KE, Mullins ES, Flick MJ, Queiroz KC, Shi K, Spek CA, Conway EM, Monia BP, Weiler H, Degen JL, Palumbo JS. Horowitz NA, et al. Blood. 2011 Sep 8;118(10):2889-95. doi: 10.1182/blood-2011-03-341222. Epub 2011 Jul 25. Blood. 2011. PMID: 21788337 Free PMC article.

4

Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor.

Vidal B, Ardite E, Suelves M, Ruiz-Bonilla V, Janué A, Flick MJ, Degen JL, Serrano AL, Muñoz-Cánoves P. Vidal B, et al. Hum Mol Genet. 2012 May 1;21(9):1989-2004. doi: 10.1093/hmg/dds012. Epub 2012 Mar 1. Hum Mol Genet. 2012. PMID: 22381526 Free PMC article.

5

Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload.

Meyer A, Wang W, Qu J, Croft L, Degen JL, Coller BS, Ahamed J. Meyer A, et al. Blood. 2012 Jan 26;119(4):1064-74. doi: 10.1182/blood-2011-09-377648. Epub 2011 Dec 1. Blood. 2012. PMID: 22134166 Free PMC article.

6

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.

Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick MJ, Degen JL. Mullins ES, et al. Blood. 2009 Jan 15;113(3):696-704. doi: 10.1182/blood-2008-07-169003. Epub 2008 Oct 16. Blood. 2009. PMID: 18927430 Free PMC article.

7

The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.

Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD, Degen JL. Flick MJ, et al. Blood. 2011 Jun 9;117(23):6326-37. doi: 10.1182/blood-2010-08-304915. Epub 2011 Mar 24. Blood. 2011. PMID: 21436072 Free PMC article.

8

Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation.

Prasad JM, Negrón O, Du X, Mullins ES, Palumbo JS, Gilbertie JM, Höök M, Grover SP, Pawlinski R, Mackman N, Degen JL, Flick MJ. Prasad JM, et al. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2009837118. doi: 10.1073/pnas.2009837118. Epub 2020 Dec 21. Proc Natl Acad Sci U S A. 2021. PMID: 33443167 Free PMC article.

9

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia.

Flick MJ, Du X, Prasad JM, Raghu H, Palumbo JS, Smeds E, Höök M, Degen JL. Flick MJ, et al. Blood. 2013 Mar 7;121(10):1783-94. doi: 10.1182/blood-2012-09-453894. Epub 2013 Jan 8. Blood. 2013. PMID: 23299312 Free PMC article.

10

Reduced thrombin generation increases host susceptibility to group A streptococcal infection.

Sun H, Wang X, Degen JL, Ginsburg D. Sun H, et al. Blood. 2009 Feb 5;113(6):1358-64. doi: 10.1182/blood-2008-07-170506. Epub 2008 Dec 3. Blood. 2009. PMID: 19056689 Free PMC article.

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