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JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice.
Sakai H, Kamuro H, Tokunoh N, Izawa T, Tamiya S, Yamamoto A, Tanaka S, Okuzaki D, Ono C, Matsuura Y, Okada Y, Yoshioka Y, Fujio Y, Obana M. Sakai H, et al. Am J Physiol Renal Physiol. 2024 Jun 1;326(6):F931-F941. doi: 10.1152/ajprenal.00011.2024. Epub 2024 Apr 18. Am J Physiol Renal Physiol. 2024. PMID: 38634132 Free PMC article.
Suppression of Dad1 induces cardiomyocyte death by weakening cell adhesion.
Mori S, Kimura R, Morihara H, Tomimatsu M, Fuchigami S, Matsumoto K, Tanaka S, Okada Y, Maeda M, Obana M, Fujio Y. Mori S, et al. Am J Physiol Cell Physiol. 2024 Nov 29. doi: 10.1152/ajpcell.00509.2024. Online ahead of print. Am J Physiol Cell Physiol. 2024. PMID: 39611549 Free article.