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The informatics of ADNI.
Toga AW, Neu S, Sheehan ST, Crawford K; Alzheimer's Disease Neuroimaging Initiative. Toga AW, et al. Alzheimers Dement. 2024 Oct;20(10):7320-7330. doi: 10.1002/alz.14099. Epub 2024 Aug 14. Alzheimers Dement. 2024. PMID: 39140398 Free PMC article. Review.
The Alzheimer's Disease Neuroimaging Initiative (ADNI) has revolutionized the landscape of Alzheimer's research through its Informatics Core, which has facilitated unprecedented data standardization and sharing. ...HIGHLIGHTS: Acceleratin …
The Alzheimer's Disease Neuroimaging Initiative (ADNI) has revolutionized the landscape of Alzheimer's …
Contributions of the ADNI Biostatistics Core.
Beckett LA, Saito N, Donohue MC, Harvey DJ; Alzheimer's Disease Neuroimaging Initiative. Beckett LA, et al. Alzheimers Dement. 2024 Oct;20(10):7331-7339. doi: 10.1002/alz.14159. Epub 2024 Aug 14. Alzheimers Dement. 2024. PMID: 39140601 Free PMC article. Review.
The goal of the Biostatistics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been to ensure that sound study designs and statistical methods are used to meet the overall goals of ADNI. ...ADNI-4 will offer us a chance to help extend these …
The goal of the Biostatistics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been to ensure that so …
Associations between misfolded alpha-synuclein aggregates and Alzheimer's disease pathology in vivo.
Pichet Binette A, Mammana A, Wisse L, Rossi M, Strandberg O, Smith R, Mattsson-Carlgren N, Janelidze S, Palmqvist S; ADNI; Ticca A, Stomrud E, Parchi P, Hansson O. Pichet Binette A, et al. Alzheimers Dement. 2024 Nov;20(11):7624-7634. doi: 10.1002/alz.14225. Epub 2024 Sep 11. Alzheimers Dement. 2024. PMID: 39258841 Free PMC article.
INTRODUCTION: We examined the relations of misfolded alpha synuclein (alpha-synuclein) with Alzheimer's disease (AD) biomarkers in two large independent cohorts. METHODS: We included Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably Tw …
INTRODUCTION: We examined the relations of misfolded alpha synuclein (alpha-synuclein) with Alzheimer's disease (AD) bi …
Biomarker pathway heterogeneity of amyloid-positive individuals.
Prosser L, Sudre CH, Oxtoby NP, Young AL, Malone IB, Manning EN, Pemberton H, Walsh P, Barkhof F, Biessels GJ, Cash DM, Barnes J; Alzheimer's Disease Neuroimaging Initiative. Prosser L, et al. Alzheimers Dement. 2024 Oct 17. doi: 10.1002/alz.14287. Online ahead of print. Alzheimers Dement. 2024. PMID: 39417393
A third subtype (n = 100) had early p-tau changes, and reflected typical Alzheimer's disease. Some amyloid positive (n = 43) individuals were similar to the amyloid-negative group. ...Heterogeneity reflected Alzheimer's disease-like, vasc …
A third subtype (n = 100) had early p-tau changes, and reflected typical Alzheimer's disease. Some amyloid positive (n …
Utility of cerebrovascular imaging biomarkers to detect cerebral amyloidosis.
Howe MD, Caruso MR, Manoochehri M, Kunicki ZJ, Emrani S, Rudolph JL, Huey ED, Salloway SP, Oh H; Alzheimer's Disease Neuroimaging Initiative. Howe MD, et al. Alzheimers Dement. 2024 Oct;20(10):7220-7231. doi: 10.1002/alz.14207. Epub 2024 Sep 1. Alzheimers Dement. 2024. PMID: 39219209 Free PMC article.
METHODS: We cross-sectionally analyzed data from the Alzheimer's Disease Neuroimaging Initiative (ADNI, N = 1352). Logistic regression was used to calculate odds ratios (ORs), with Abeta-PET positivity as the standard-of-truth. ...HIGHLIGHTS: Cerebrovascular …
METHODS: We cross-sectionally analyzed data from the Alzheimer's Disease Neuroimaging Initiative (ADNI, N = 1352). Logi …
Potential role of blood pressure variability and plasma neurofilament light in the mechanism of comorbidity between Alzheimer's disease and cerebral small vessel disease.
Li Q, Su S, Feng Y, Jia M, Zhan J, Liao Z, Li J, Li X; Alzheimer's Disease Neuroimaging Initiative. Li Q, et al. Alzheimers Dement. 2024 Jul;20(7):4891-4902. doi: 10.1002/alz.14056. Epub 2024 Jun 19. Alzheimers Dement. 2024. PMID: 38895921 Free PMC article.
INTRODUCTION: Long-term blood pressure variability (BPV) and plasma neurofilament light (pNfL) have been identified as potential biomarkers for Alzheimer's disease (AD) and cerebral small vessel disease (CSVD). However, the relationship between BPV, pN …
INTRODUCTION: Long-term blood pressure variability (BPV) and plasma neurofilament light (pNfL) have been identified as potential biomarkers …
The Health Equity Scholars Program: Fostering Culturally Competent and Successful Independent Investigators in Alzheimer's Disease and Related Dementia Research.
Amaza H, Niay A, Thao MS, Strong J, Arentoft A, Guzman V, O'Bryant SE, Weiner M, Mindt MR, Okonkwo OC; Alzheimer's Disease Neuroimaging Initiative; HABS‐HD Investigative Team. Amaza H, et al. Alzheimers Dement. 2024 Nov 7. doi: 10.1002/alz.14323. Online ahead of print. Alzheimers Dement. 2024. PMID: 39511895
INTRODUCTION: The Health Equity Scholars Program (HESP) addresses the critical need for a diverse, culturally competent workforce to study and treat older adults from underrepresented populations (URPs) with Alzheimer's disease and related dementias (AD/ADRD) …
INTRODUCTION: The Health Equity Scholars Program (HESP) addresses the critical need for a diverse, culturally competent workforce to study a …
Stress testing the Centiloid: Precision and variability of PET quantification of amyloid pathology.
Shekari M, Vállez García D, Collij LE, Altomare D, Heeman F, Pemberton H, Roé Vellvé N, Bullich S, Buckley C, Stephens A, Farrar G, Frisoni G, Klunk WE, Barkhof F, Gispert JD; ADNI and the AMYPAD consortium. Shekari M, et al. Alzheimers Dement. 2024 Aug;20(8):5102-5113. doi: 10.1002/alz.13883. Epub 2024 Jul 4. Alzheimers Dement. 2024. PMID: 38961808 Free PMC article.
METHODS: We included 533 participants from AMYloid imaging to Prevent Alzheimer's Disease (AMYPAD DPMS) and Alzheimer's Disease Neuroimaging Initiative (ADNI) cohorts. ...Confidence intervals should be considered when operationalizing CL …
METHODS: We included 533 participants from AMYloid imaging to Prevent Alzheimer's Disease (AMYPAD DPMS) and Alzheime …
Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers.
Liu S, Park T, Krüger DM, Pena-Centeno T, Burkhardt S, Schutz AL, Huang YN, Rosewood T, Chaudhuri S, Cho M, Risacher SL, Wan Y, Shaw LM, Sananbenesi F, Brodsky AS, Lin H, Krunic A, Blusztajn JK, Saykin AJ, Delalle I, Fischer A, Nho K; Alzheimer's Disease Neuroimaging Initiative. Liu S, et al. Alzheimers Dement. 2024 Nov;20(11):7698-7714. doi: 10.1002/alz.14230. Epub 2024 Sep 18. Alzheimers Dement. 2024. PMID: 39291737 Free PMC article.
INTRODUCTION: MicroRNAs (miRNAs) play important roles in gene expression regulation and Alzheimer's disease (AD) pathogenesis. METHODS: We investigated the association between baseline plasma miRNAs and central AD biomarkers from the Alzheimer's …
INTRODUCTION: MicroRNAs (miRNAs) play important roles in gene expression regulation and Alzheimer's disease (AD) pathog …
Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry.
Ray NR, Kunkle BW, Hamilton-Nelson K, Kurup JT, Rajabli F, Qiao M, Vardarajan BN, Cosacak MI, Kizil C, Jean-Francois M, Cuccaro M, Reyes-Dumeyer D, Cantwell L, Kuzma A, Vance JM, Gao S, Hendrie HC, Baiyewu O, Ogunniyi A, Akinyemi RO; Alzheimer's Disease Genetics Consortium; Lee WP, Martin ER, Wang LS, Beecham GW, Bush WS, Xu W, Jin F, Wang L, Farrer LA, Haines JL, Byrd GS, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C. Ray NR, et al. Alzheimers Dement. 2024 Aug;20(8):5247-5261. doi: 10.1002/alz.13880. Epub 2024 Jul 3. Alzheimers Dement. 2024. PMID: 38958117 Free PMC article.
HIGHLIGHTS: Genetic ancestry significantly impacts risk of Alzheimer's Disease (AD). Although individuals of African ancestry are twice as likely to develop AD, they are vastly underrepresented in AD genomics studies. The Alzheimer's Disease …
HIGHLIGHTS: Genetic ancestry significantly impacts risk of Alzheimer's Disease (AD). Although individuals of African an …
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