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Page 1
Cell type-selective secretome profiling in vivo.
Wei W, Riley NM, Yang AC, Kim JT, Terrell SM, Li VL, Garcia-Contreras M, Bertozzi CR, Long JZ. Wei W, et al. Nat Chem Biol. 2021 Mar;17(3):326-334. doi: 10.1038/s41589-020-00698-y. Epub 2020 Nov 16. Nat Chem Biol. 2021. PMID: 33199915 Free PMC article.
MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint.
Smith BAH, Deutzmann A, Correa KM, Delaveris CS, Dhanasekaran R, Dove CG, Sullivan DK, Wisnovsky S, Stark JC, Pluvinage JV, Swaminathan S, Riley NM, Rajan A, Majeti R, Felsher DW, Bertozzi CR. Smith BAH, et al. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2215376120. doi: 10.1073/pnas.2215376120. Epub 2023 Mar 10. Proc Natl Acad Sci U S A. 2023. PMID: 36897988 Free PMC article.
Revealing the human mucinome.
Malaker SA, Riley NM, Shon DJ, Pedram K, Krishnan V, Dorigo O, Bertozzi CR. Malaker SA, et al. Nat Commun. 2022 Jun 20;13(1):3542. doi: 10.1038/s41467-022-31062-4. Nat Commun. 2022. PMID: 35725833 Free PMC article.
The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.
Richards CM, Jabs S, Qiao W, Varanese LD, Schweizer M, Mosen PR, Riley NM, Klüssendorf M, Zengel JR, Flynn RA, Rustagi A, Widen JC, Peters CE, Ooi YS, Xie X, Shi PY, Bartenschlager R, Puschnik AS, Bogyo M, Bertozzi CR, Blish CA, Winter D, Nagamine CM, Braulke T, Carette JE. Richards CM, et al. Science. 2022 Oct 7;378(6615):eabn5648. doi: 10.1126/science.abn5648. Epub 2022 Oct 7. Science. 2022. PMID: 36074821 Free PMC article.
Design of a mucin-selective protease for targeted degradation of cancer-associated mucins.
Pedram K, Shon DJ, Tender GS, Mantuano NR, Northey JJ, Metcalf KJ, Wisnovsky SP, Riley NM, Forcina GC, Malaker SA, Kuo A, George BM, Miller CL, Casey KM, Vilches-Moure JG, Ferracane MJ, Weaver VM, Läubli H, Bertozzi CR. Pedram K, et al. Nat Biotechnol. 2024 Apr;42(4):597-607. doi: 10.1038/s41587-023-01840-6. Epub 2023 Aug 3. Nat Biotechnol. 2024. PMID: 37537499 Free PMC article.
The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C.
Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pașca AM, Pașca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T. Pluvinage JV, et al. Sci Transl Med. 2021 Dec;13(622):eabg2919. doi: 10.1126/scitranslmed.abg2919. Epub 2021 Dec 1. Sci Transl Med. 2021. PMID: 34851695 Free PMC article.
26 results