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A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8.
Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL. Seed RI, et al. Sci Immunol. 2021 Mar 26;6(57):eabf0558. doi: 10.1126/sciimmunol.abf0558. Sci Immunol. 2021. PMID: 33771888 Free PMC article.
An OX40/OX40L interaction directs successful immunity to hepatitis B virus.
Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL. Publicover J, et al. Sci Transl Med. 2018 Mar 21;10(433):eaah5766. doi: 10.1126/scitranslmed.aah5766. Sci Transl Med. 2018. PMID: 29563320 Free PMC article.
Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells.
Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL. Takasaka N, et al. JCI Insight. 2018 Oct 18;3(20):e122591. doi: 10.1172/jci.insight.122591. JCI Insight. 2018. PMID: 30333313 Free PMC article.