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Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.
Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI. Ko DC, et al. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2343-52. doi: 10.1073/pnas.1206701109. Epub 2012 Jul 25. Proc Natl Acad Sci U S A. 2012. PMID: 22837397 Free PMC article.
Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol.
Alvarez MI, Glover LC, Luo P, Wang L, Theusch E, Oehlers SH, Walton EM, Tram TTB, Kuang YL, Rotter JI, McClean CM, Chinh NT, Medina MW, Tobin DM, Dunstan SJ, Ko DC. Alvarez MI, et al. Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7746-E7755. doi: 10.1073/pnas.1706070114. Epub 2017 Aug 21. Proc Natl Acad Sci U S A. 2017. PMID: 28827342 Free PMC article.