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Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis.
Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO. Eltobgy MM, et al. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2202012119. doi: 10.1073/pnas.2202012119. Epub 2022 May 19. Proc Natl Acad Sci U S A. 2022. PMID: 35588457 Free PMC article.
MEK1/2 inhibition decreases pro-inflammatory responses in macrophages from people with cystic fibrosis and mitigates severity of illness in experimental murine methicillin-resistant Staphylococcus aureus infection.
De M, Serpa G, Zuiker E, Hisert KB, Liles WC, Manicone AM, Hemann EA, Long ME. De M, et al. Front Cell Infect Microbiol. 2024 Jan 30;14:1275940. doi: 10.3389/fcimb.2024.1275940. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 38352056 Free PMC article.
Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation.
Speaks S, Zani A, Solstad A, Kenney A, McFadden MI, Zhang L, Eddy AC, Amer AO, Robinson R, Cai C, Ma J, Hemann EA, Forero A, Yount JS. Speaks S, et al. bioRxiv [Preprint]. 2023 Apr 7:2023.03.08.531787. doi: 10.1101/2023.03.08.531787. bioRxiv. 2023. Update in: Nat Commun. 2024 Mar 29;15(1):2751. doi: 10.1038/s41467-024-47067-0 PMID: 36945485 Free PMC article. Updated. Preprint.
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