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The new type 2 diabetes gene TCF7L2.
Florez JC. Florez JC. Curr Opin Clin Nutr Metab Care. 2007 Jul;10(4):391-6. doi: 10.1097/MCO.0b013e3281e2c9be. Curr Opin Clin Nutr Metab Care. 2007. PMID: 17563454 Review.
Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.
Saxena R, Gianniny L, Burtt NP, Lyssenko V, Giuducci C, Sjögren M, Florez JC, Almgren P, Isomaa B, Orho-Melander M, Lindblad U, Daly MJ, Tuomi T, Hirschhorn JN, Ardlie KG, Groop LC, Altshuler D. Saxena R, et al. Diabetes. 2006 Oct;55(10):2890-5. doi: 10.2337/db06-0381. Diabetes. 2006. PMID: 17003358
Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.
Florez JC, Jablonski KA, Sun MW, Bayley N, Kahn SE, Shamoon H, Hamman RF, Knowler WC, Nathan DM, Altshuler D; Diabetes Prevention Program Research Group. Florez JC, et al. J Clin Endocrinol Metab. 2007 Apr;92(4):1502-9. doi: 10.1210/jc.2006-2275. Epub 2007 Jan 9. J Clin Endocrinol Metab. 2007. PMID: 17213274 Free PMC article. Clinical Trial.