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Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits.
PLoS One. 2011;6(9):e25416. doi: 10.1371/journal.pone.0025416. Epub 2011 Sep 28.
PLoS One. 2011.
PMID: 21980451
Free PMC article.
Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling.
Majumder S, Caccamo A, Medina DX, Benavides AD, Javors MA, Kraig E, Strong R, Richardson A, Oddo S.
Majumder S, et al.
Aging Cell. 2012 Apr;11(2):326-35. doi: 10.1111/j.1474-9726.2011.00791.x. Epub 2012 Feb 1.
Aging Cell. 2012.
PMID: 22212527
Free PMC article.
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