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Some recommendations for multi-arm multi-stage trials.
Wason J, Magirr D, Law M, Jaki T. Wason J, et al. Stat Methods Med Res. 2016 Apr;25(2):716-27. doi: 10.1177/0962280212465498. Epub 2012 Dec 12. Stat Methods Med Res. 2016. PMID: 23242385 Free PMC article.
TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy.
Pushpakom S, Kolamunnage-Dona R, Taylor C, Foster T, Spowart C, García-Fiñana M, Kemp GJ, Jaki T, Khoo S, Williamson P, Pirmohamed M; TAILoR Study Group. Pushpakom S, et al. Clin Infect Dis. 2020 May 6;70(10):2062-2072. doi: 10.1093/cid/ciz589. Clin Infect Dis. 2020. PMID: 31425580 Free PMC article. Clinical Trial.
Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of telmisartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on combination antiretroviral therapy.
Pushpakom SP, Taylor C, Kolamunnage-Dona R, Spowart C, Vora J, García-Fiñana M, Kemp GJ, Whitehead J, Jaki T, Khoo S, Williamson P, Pirmohamed M. Pushpakom SP, et al. BMJ Open. 2015 Oct 15;5(10):e009566. doi: 10.1136/bmjopen-2015-009566. BMJ Open. 2015. PMID: 26474943 Free PMC article. Clinical Trial.