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High-throughput screening for small-molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson's disease.
Williams D, Glasstetter LM, Jong TT, Chen T, Kapoor A, Zhu S, Zhu Y, Calvo R, Gehrlein A, Wong K, Hogan AN, Vocadlo DJ, Jagasia R, Marugan JJ, Sidransky E, Henderson MJ, Chen Y. Williams D, et al. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2406009121. doi: 10.1073/pnas.2406009121. Epub 2024 Oct 10. Proc Natl Acad Sci U S A. 2024. PMID: 39388267 Free PMC article.
Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress.
Eldeeb MA, Bayne AN, Fallahi A, Goiran T, MacDougall EJ, Soumbasis A, Zorca CE, Tabah JJ, Thomas RA, Karpilovsky N, Mathur M, Durcan TM, Trempe JF, Fon EA. Eldeeb MA, et al. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2313540121. doi: 10.1073/pnas.2313540121. Epub 2024 Feb 28. Proc Natl Acad Sci U S A. 2024. PMID: 38416681 Free PMC article.
Measurement of α-synuclein as protein cargo in plasma extracellular vesicles.
Gilboa T, Ter-Ovanesyan D, Wang SC, Whiteman S, Kannarkat GT, Church GM, Chen-Plotkin AS, Walt DR. Gilboa T, et al. Proc Natl Acad Sci U S A. 2024 Nov 5;121(45):e2408949121. doi: 10.1073/pnas.2408949121. Epub 2024 Oct 30. Proc Natl Acad Sci U S A. 2024. PMID: 39475636 Free article.
12 results