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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 11
1947 5
1948 9
1949 4
1950 3
1951 9
1952 6
1953 7
1954 5
1955 2
1956 11
1957 11
1958 7
1959 5
1960 6
1961 9
1962 14
1963 21
1964 12
1965 26
1966 30
1967 50
1968 89
1969 132
1970 193
1971 372
1972 523
1973 585
1974 698
1975 805
1976 811
1977 816
1978 761
1979 808
1980 894
1981 867
1982 838
1983 947
1984 1024
1985 1079
1986 1078
1987 1020
1988 1091
1989 1253
1990 1219
1991 1315
1992 1361
1993 1386
1994 1528
1995 1616
1996 1614
1997 1543
1998 1454
1999 1430
2000 1525
2001 1545
2002 1563
2003 1529
2004 1537
2005 1466
2006 1481
2007 1444
2008 1439
2009 1392
2010 1399
2011 1451
2012 1499
2013 1419
2014 1464
2015 1497
2016 1580
2017 1425
2018 1758
2019 1927
2020 2082
2021 2175
2022 3661
2023 1789
2024 1779
2025 24

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68,501 results

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Page 1
New P2Y12 blockers.
Cattaneo M. Cattaneo M. J Thromb Haemost. 2009 Jul;7 Suppl 1:262-5. doi: 10.1111/j.1538-7836.2009.03382.x. J Thromb Haemost. 2009. PMID: 19630813 Free article. Review.
Prasugrel, a third-generation, oral thienopyridine, has been shown to be superior to clopidogrel, the current gold standard, in preventing ischemic events in patients with ACS undergoing percutaneous coronary intervention (PCI), although the bleeding rate was higher. Cangrelor, a …
Prasugrel, a third-generation, oral thienopyridine, has been shown to be superior to clopidogrel, the current gold standard, in preventing i …
Purinergic signalling: pathophysiological roles.
Abbracchio MP, Burnstock G. Abbracchio MP, et al. Jpn J Pharmacol. 1998 Oct;78(2):113-45. doi: 10.1254/jjp.78.113. Jpn J Pharmacol. 1998. PMID: 9829617 Free article. Review.
Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors.
Lux MC, Standke LC, Tan DS. Lux MC, et al. J Antibiot (Tokyo). 2019 Jun;72(6):325-349. doi: 10.1038/s41429-019-0171-2. Epub 2019 Apr 15. J Antibiot (Tokyo). 2019. PMID: 30982830 Free PMC article. Review.
They catalyze ATP-dependent activation of carboxylic acid substrates as reactive acyl adenylate (acyl-AMP) intermediates and subsequent coupling to various nucleophiles to generate ester, thioester, and amide products. Inspired by natural products, acyl sulfonyladenosines …
They catalyze ATP-dependent activation of carboxylic acid substrates as reactive acyl adenylate (acyl-AMP) intermediates and subseque …
Regulatory approval for COVID-19 across the globe.
Mahalmani V, Pugazhenthan T, Mittal N, Varthya SB, Medhi B. Mahalmani V, et al. Indian J Pharmacol. 2020 Nov-Dec;52(6):457-466. doi: 10.4103/ijp.ijp_32_21. Indian J Pharmacol. 2020. PMID: 33666185 Free PMC article. No abstract available.
The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary disease.
van den Berge M, Polosa R, Kerstjens HA, Postma DS. van den Berge M, et al. J Allergy Clin Immunol. 2004 Oct;114(4):737-46. doi: 10.1016/j.jaci.2004.05.071. J Allergy Clin Immunol. 2004. PMID: 15480309 Review.
Another possible stimulus to measure bronchial hyperresponsiveness is AMP. AMP is an indirect stimulus, because it acts via the release of histamine and other mediators from immunologically primed mast cells. There is increasing interest in the role of AMP as …
Another possible stimulus to measure bronchial hyperresponsiveness is AMP. AMP is an indirect stimulus, because it acts via th …
Cangrelor: The Paradox of Choice.
Brar SS. Brar SS. J Am Coll Cardiol. 2017 Jan 17;69(2):186-188. doi: 10.1016/j.jacc.2016.11.020. J Am Coll Cardiol. 2017. PMID: 28081828 Free article. No abstract available.
Cyclic AMP and psoriasis.
Halprin KM, Adachi K, Yoshikawa K, Levine V, Mui MM, Hsia SL. Halprin KM, et al. J Invest Dermatol. 1975 Jul;65(1):170-8. doi: 10.1111/1523-1747.ep12598119. J Invest Dermatol. 1975. PMID: 239070 Free article.
Despite this lack of response to external agents which elevate cyclic AMP, the concentration of cyclic AMP within the epidermis of the psoriatic lesion is no lower than in noninvolved skin. ...
Despite this lack of response to external agents which elevate cyclic AMP, the concentration of cyclic AMP within the epidermi …
Cangrelor - a champion lost in translation?
Kastrati A, Ndrepepa G. Kastrati A, et al. N Engl J Med. 2009 Dec 10;361(24):2382-4. doi: 10.1056/NEJMe0910677. N Engl J Med. 2009. PMID: 19915223 No abstract available.
Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligases.
Pergolizzi G, Cominetti MM, Butt JN, Field RA, Bowater RP, Wagner GK. Pergolizzi G, et al. Org Biomol Chem. 2015 Jun 14;13(22):6380-98. doi: 10.1039/c5ob00294j. Org Biomol Chem. 2015. PMID: 25974621
We report the chemical synthesis and conformational analysis of a collection of 2-, 6- and 8-substituted derivatives of beta-NAD(+) and AMP, and their biochemical evaluation against NAD(+)-dependent DNA ligases from Escherichia coli and Mycobacterium tuberculosis. ...Our s …
We report the chemical synthesis and conformational analysis of a collection of 2-, 6- and 8-substituted derivatives of beta-NAD(+) and A …
USA stockpiling of remdesivir: How should the world respond?
Dawoud D, Chalkidou K, Sullivan R, Ruiz FJ, Adler A. Dawoud D, et al. J Comp Eff Res. 2020 Dec;9(18):1243-1246. doi: 10.2217/cer-2020-0174. Epub 2020 Dec 4. J Comp Eff Res. 2020. PMID: 33274643 Free PMC article. Review.
68,501 results
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