The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity

The small molecule CLP257 does not modify activity of the K⁺-Cl^- co-transporter KCC2 but does potentiate GABA_A receptor activity

Nat Med. 2017 Dec 7;23(12):1394-1396. doi: 10.1038/nm.4442.

Ross A Cardarelli¹, Karen Jones², Lucie I Pisella^{3

4}, Heike J Wobst^{1

5}, Lisa J McWilliams⁶, Paul M Sharpe², Matthew P Burnham², David J Baker⁶, Ilona Chudotvorova^{3

4}, Justine Guyot^{3

4}, Liliya Silayeva¹, Danielle H Morrow⁷, Niek Dekker⁸, Stephen Zicha⁵, Paul A Davies⁷, Jörg Holenz⁵, Mark E Duggan⁵, John Dunlop⁵, Robert J Mather⁵, Qi Wang^{1

5}, Igor Medina^{3

4}, Nicholas J Brandon^{1

5}, Tarek Z Deeb¹, Stephen J Moss^{1

7

9}

¹ AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.
² Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK.
³ INMED, INSERM, Unité 901, Marseille, France.
⁴ Aix-Marseille Université, UMR 901, Marseille, France.
⁵ Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA.
⁶ Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
⁷ Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
⁸ Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
⁹ Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.

No abstract available