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Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells.
Liu R, O'Connell M, Johnson K, Pritzker K, Mackman N, Terkeltaub R. Liu R, et al. Arthritis Rheum. 2000 May;43(5):1145-55. doi: 10.1002/1529-0131(200005)43:5<1145::AID-ANR25>3.0.CO;2-T. Arthritis Rheum. 2000. PMID: 10817569 Free article.
Parathyroid hormone-related proteins is abundant in osteoarthritic cartilage, and the parathyroid hormone-related protein 1-173 isoform is selectively induced by transforming growth factor beta in articular chondrocytes and suppresses generation of extracellular inorganic pyrophosphate.
Terkeltaub R, Lotz M, Johnson K, Deng D, Hashimoto S, Goldring MB, Burton D, Deftos LJ. Terkeltaub R, et al. Arthritis Rheum. 1998 Dec;41(12):2152-64. doi: 10.1002/1529-0131(199812)41:12<2152::AID-ART10>3.0.CO;2-X. Arthritis Rheum. 1998. PMID: 9870872
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