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Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance.
Kumashiro N, Beddow SA, Vatner DF, Majumdar SK, Cantley JL, Guebre-Egziabher F, Fat I, Guigni B, Jurczak MJ, Birkenfeld AL, Kahn M, Perler BK, Puchowicz MA, Manchem VP, Bhanot S, Still CD, Gerhard GS, Petersen KF, Cline GW, Shulman GI, Samuel VT. Kumashiro N, et al. Diabetes. 2013 Jul;62(7):2183-94. doi: 10.2337/db12-1311. Epub 2013 Feb 19. Diabetes. 2013. PMID: 23423574 Free PMC article.
Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice.
Camporez JP, Jornayvaz FR, Petersen MC, Pesta D, Guigni BA, Serr J, Zhang D, Kahn M, Samuel VT, Jurczak MJ, Shulman GI. Camporez JP, et al. Endocrinology. 2013 Sep;154(9):3099-109. doi: 10.1210/en.2013-1191. Epub 2013 Jun 13. Endocrinology. 2013. PMID: 23766126 Free PMC article.
Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats.
Cantley JL, Vatner DF, Galbo T, Madiraju A, Petersen M, Perry RJ, Kumashiro N, Guebre-Egziabher F, Gattu AK, Stacy MR, Dione DP, Sinusas AJ, Ragolia L, Hall CE, Manchem VP, Bhanot S, Bogan JS, Samuel VT. Cantley JL, et al. Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E773-83. doi: 10.1152/ajpendo.00148.2014. Epub 2014 Aug 26. Am J Physiol Endocrinol Metab. 2014. PMID: 25159329 Free PMC article.
Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance.
Popov VB, Jornayvaz FR, Akgul EO, Kanda S, Jurczak MJ, Zhang D, Abudukadier A, Majumdar SK, Guigni B, Petersen KF, Manchem VP, Bhanot S, Shulman GI, Samuel VT. Popov VB, et al. FASEB J. 2016 Mar;30(3):1207-17. doi: 10.1096/fj.15-271999. Epub 2015 Dec 7. FASEB J. 2016. PMID: 26644352 Free PMC article.
13 results