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Combination of temsirolimus (CCI-779) with chemoradiation in newly diagnosed glioblastoma multiforme (GBM) (NCCTG trial N027D) is associated with increased infectious risks.
Sarkaria JN, Galanis E, Wu W, Dietz AB, Kaufmann TJ, Gustafson MP, Brown PD, Uhm JH, Rao RD, Doyle L, Giannini C, Jaeckle KA, Buckner JC. Sarkaria JN, et al. Clin Cancer Res. 2010 Nov 15;16(22):5573-80. doi: 10.1158/1078-0432.CCR-10-1453. Epub 2010 Oct 4. Clin Cancer Res. 2010. PMID: 20921209 Free PMC article. Clinical Trial.