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18 results

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Page 1
Synergy in activating class I PI3Ks.
Burke JE, Williams RL. Burke JE, et al. Trends Biochem Sci. 2015 Feb;40(2):88-100. doi: 10.1016/j.tibs.2014.12.003. Epub 2015 Jan 5. Trends Biochem Sci. 2015. PMID: 25573003 Review.
Allosteric activation of PI3Kα by oncogenic mutations.
Burke JE, Perisic O, Williams RL. Burke JE, et al. Oncotarget. 2013 Feb;4(2):180-1. doi: 10.18632/oncotarget.913. Oncotarget. 2013. PMID: 23563630 Free PMC article. No abstract available.
Connecting with an old partner in a new way.
Burke JE, Williams RL. Burke JE, et al. Cancer Cell. 2013 May 13;23(5):559-61. doi: 10.1016/j.ccr.2013.04.023. Cancer Cell. 2013. PMID: 23680139 Free article.
Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi.
D'Angelo G, Uemura T, Chuang CC, Polishchuk E, Santoro M, Ohvo-Rekilä H, Sato T, Di Tullio G, Varriale A, D'Auria S, Daniele T, Capuani F, Johannes L, Mattjus P, Monti M, Pucci P, Williams RL, Burke JE, Platt FM, Harada A, De Matteis MA. D'Angelo G, et al. Nature. 2013 Sep 5;501(7465):116-20. doi: 10.1038/nature12423. Epub 2013 Aug 4. Nature. 2013. PMID: 23913272
PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.
Walser R, Burke JE, Gogvadze E, Bohnacker T, Zhang X, Hess D, Küenzi P, Leitges M, Hirsch E, Williams RL, Laffargue M, Wymann MP. Walser R, et al. PLoS Biol. 2013;11(6):e1001587. doi: 10.1371/journal.pbio.1001587. Epub 2013 Jun 25. PLoS Biol. 2013. PMID: 23824069 Free PMC article.
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Bohnacker T, Prota AE, Beaufils F, Burke JE, Melone A, Inglis AJ, Rageot D, Sele AM, Cmiljanovic V, Cmiljanovic N, Bargsten K, Aher A, Akhmanova A, Díaz JF, Fabbro D, Zvelebil M, Williams RL, Steinmetz MO, Wymann MP. Bohnacker T, et al. Nat Commun. 2017 Mar 9;8:14683. doi: 10.1038/ncomms14683. Nat Commun. 2017. PMID: 28276440 Free PMC article.
Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Mevissen TET, Kulathu Y, Mulder MPC, Geurink PP, Maslen SL, Gersch M, Elliott PR, Burke JE, van Tol BDM, Akutsu M, Oualid FE, Kawasaki M, Freund SMV, Ovaa H, Komander D. Mevissen TET, et al. Nature. 2016 Oct 20;538(7625):402-405. doi: 10.1038/nature19836. Epub 2016 Oct 12. Nature. 2016. PMID: 27732584 Free PMC article.
18 results