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Page 1
Artesunate Activation by Heme in an Aqueous Medium.
Heller L, Roepe PD, de Dios AC. Heller L, et al. Inorganica Chim Acta. 2019 Oct 1;496:119029. doi: 10.1016/j.ica.2019.119029. Epub 2019 Jul 22. Inorganica Chim Acta. 2019. PMID: 32831389 Free PMC article.
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Kim J, Tan YZ, Wicht KJ, Erramilli SK, Dhingra SK, Okombo J, Vendome J, Hagenah LM, Giacometti SI, Warren AL, Nosol K, Roepe PD, Potter CS, Carragher B, Kossiakoff AA, Quick M, Fidock DA, Mancia F. Kim J, et al. Nature. 2019 Dec;576(7786):315-320. doi: 10.1038/s41586-019-1795-x. Epub 2019 Nov 27. Nature. 2019. PMID: 31776516 Free PMC article.
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology.
Hagenah LM, Dhingra SK, Small-Saunders JL, Qahash T, Willems A, Schindler KA, Rangel GW, Gil-Iturbe E, Kim J, Akhundova E, Yeo T, Okombo J, Mancia F, Quick M, Roepe PD, Llinás M, Fidock DA. Hagenah LM, et al. mBio. 2024 Jan 16;15(1):e0183223. doi: 10.1128/mbio.01832-23. Epub 2023 Dec 7. mBio. 2024. PMID: 38059639 Free PMC article.
33 results