Identification and characterization of inhibitors of the aminoglycoside resistance acetyltransferase Eis from Mycobacterium tuberculosis

ChemMedChem. 2012 Jan 2;7(1):73-7. doi: 10.1002/cmdc.201100332. Epub 2011 Sep 5.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetyltransferases / antagonists & inhibitors*
  • Acetyltransferases / metabolism
  • Aminoglycosides / pharmacology*
  • Antigens, Bacterial / metabolism
  • Antitubercular Agents / pharmacology*
  • Bacterial Proteins / antagonists & inhibitors*
  • Bacterial Proteins / metabolism
  • Drug Resistance, Bacterial / drug effects
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / enzymology*
  • Tuberculosis / drug therapy
  • Tuberculosis / enzymology

Substances

  • Aminoglycosides
  • Antigens, Bacterial
  • Antitubercular Agents
  • Bacterial Proteins
  • Enzyme Inhibitors
  • Acetyltransferases
  • Eis protein, Mycobacterium tuberculosis
  • aminoglycoside acetyltransferase