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Polymerases of paramyxoviruses and pneumoviruses.
Fearns R, Plemper RK. Fearns R, et al. Virus Res. 2017 Apr 15;234:87-102. doi: 10.1016/j.virusres.2017.01.008. Epub 2017 Jan 16. Virus Res. 2017. PMID: 28104450 Free PMC article. Review.
Structure of the human metapneumovirus polymerase phosphoprotein complex.
Pan J, Qian X, Lattmann S, El Sahili A, Yeo TH, Jia H, Cressey T, Ludeke B, Noton S, Kalocsay M, Fearns R, Lescar J. Pan J, et al. Nature. 2020 Jan;577(7789):275-279. doi: 10.1038/s41586-019-1759-1. Epub 2019 Nov 7. Nature. 2020. PMID: 31698413 Free PMC article.
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.
Warren TK, Jordan R, Lo MK, Ray AS, Mackman RL, Soloveva V, Siegel D, Perron M, Bannister R, Hui HC, Larson N, Strickley R, Wells J, Stuthman KS, Van Tongeren SA, Garza NL, Donnelly G, Shurtleff AC, Retterer CJ, Gharaibeh D, Zamani R, Kenny T, Eaton BP, Grimes E, Welch LS, Gomba L, Wilhelmsen CL, Nichols DK, Nuss JE, Nagle ER, Kugelman JR, Palacios G, Doerffler E, Neville S, Carra E, Clarke MO, Zhang L, Lew W, Ross B, Wang Q, Chun K, Wolfe L, Babusis D, Park Y, Stray KM, Trancheva I, Feng JY, Barauskas O, Xu Y, Wong P, Braun MR, Flint M, McMullan LK, Chen SS, Fearns R, Swaminathan S, Mayers DL, Spiropoulou CF, Lee WA, Nichol ST, Cihlar T, Bavari S. Warren TK, et al. Nature. 2016 Mar 17;531(7594):381-5. doi: 10.1038/nature17180. Epub 2016 Mar 2. Nature. 2016. PMID: 26934220 Free PMC article.
Ebolavirus polymerase uses an unconventional genome replication mechanism.
Deflubé LR, Cressey TN, Hume AJ, Olejnik J, Haddock E, Feldmann F, Ebihara H, Fearns R, Mühlberger E. Deflubé LR, et al. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8535-8543. doi: 10.1073/pnas.1815745116. Epub 2019 Apr 8. Proc Natl Acad Sci U S A. 2019. PMID: 30962389 Free PMC article.
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