R01 AI132154/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2018	1
2019	6
2020	12
2021	3
2022	3
2023	4
2024	1

1

Rescuing the Last-Line Polymyxins: Achievements and Challenges.

Nang SC, Azad MAK, Velkov T, Zhou QT, Li J. Nang SC, et al. Pharmacol Rev. 2021 Apr;73(2):679-728. doi: 10.1124/pharmrev.120.000020. Pharmacol Rev. 2021. PMID: 33627412 Free PMC article. Review.

2

Regulating polymyxin resistance in Gram-negative bacteria: roles of two-component systems PhoPQ and PmrAB.

Huang J, Li C, Song J, Velkov T, Wang L, Zhu Y, Li J. Huang J, et al. Future Microbiol. 2020 Apr;15(6):445-459. doi: 10.2217/fmb-2019-0322. Epub 2020 Apr 6. Future Microbiol. 2020. PMID: 32250173 Free PMC article. Review.

3

The rise and spread of mcr plasmid-mediated polymyxin resistance.

Nang SC, Li J, Velkov T. Nang SC, et al. Crit Rev Microbiol. 2019 Mar;45(2):131-161. doi: 10.1080/1040841X.2018.1492902. Epub 2019 May 23. Crit Rev Microbiol. 2019. PMID: 31122100 Free PMC article. Review.

4

Molecular Insights to the Structure-Interaction Relationships of Human Proton-Coupled Oligopeptide Transporters (PepTs).

Luo Y, Gao J, Jiang X, Zhu L, Zhou QT, Murray M, Li J, Zhou F. Luo Y, et al. Pharmaceutics. 2023 Oct 23;15(10):2517. doi: 10.3390/pharmaceutics15102517. Pharmaceutics. 2023. PMID: 37896276 Free PMC article. Review.

5

Treatment of infections caused by Gram-negative pathogens: current status on the pharmacokinetics/pharmacodynamics of parenteral and inhaled polymyxins in patients.

Lin YW, Aye SM, Rao G, Zhou QT, Chan HK, Li J. Lin YW, et al. Int J Antimicrob Agents. 2020 Dec;56(6):106199. doi: 10.1016/j.ijantimicag.2020.106199. Epub 2020 Oct 17. Int J Antimicrob Agents. 2020. PMID: 33075510 Free PMC article. Review.

6

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens.

Roberts KD, Zhu Y, Azad MAK, Han ML, Wang J, Wang L, Yu HH, Horne AS, Pinson JA, Rudd D, Voelcker NH, Patil NA, Zhao J, Jiang X, Lu J, Chen K, Lomovskaya O, Hecker SJ, Thompson PE, Nation RL, Dudley MN, Griffith DC, Velkov T, Li J. Roberts KD, et al. Nat Commun. 2022 Mar 25;13(1):1625. doi: 10.1038/s41467-022-29234-3. Nat Commun. 2022. PMID: 35338128 Free PMC article.

7

Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity.

Lu J, Azad MAK, Moreau JLM, Zhu Y, Jiang X, Tonta M, Lam R, Wickremasinghe H, Zhao J, Wang J, Coleman HA, Formosa LE, Velkov T, Parkington HC, Combes AN, Rosenbluh J, Li J. Lu J, et al. Cell Mol Life Sci. 2022 May 15;79(6):296. doi: 10.1007/s00018-022-04316-z. Cell Mol Life Sci. 2022. PMID: 35570209 Free PMC article.

8

Structure-Interaction Relationship of Polymyxins with Lung Surfactant.

Jiang X, Patil NA, Xu Y, Wickremasinghe H, Zhou QT, Zhou F, Thompson PE, Wang L, Xiao M, Roberts KD, Velkov T, Li J. Jiang X, et al. J Med Chem. 2023 Dec 14;66(23):16109-16119. doi: 10.1021/acs.jmedchem.3c01497. Epub 2023 Nov 29. J Med Chem. 2023. PMID: 38019899

9

Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity.

Patil NA, Ma W, Jiang X, He X, Yu HH, Wickremasinghe H, Wang J, Thompson PE, Velkov T, Roberts KD, Li J. Patil NA, et al. J Med Chem. 2023 Feb 23;66(4):2865-2876. doi: 10.1021/acs.jmedchem.2c01915. Epub 2023 Feb 6. J Med Chem. 2023. PMID: 36745479

10

Lipid A Modification and Metabolic Adaptation in Polymyxin-Resistant, New Delhi Metallo-β-Lactamase-Producing Klebsiella pneumoniae.

Lu J, Han M, Yu HH, Bergen PJ, Liu Y, Zhao J, Wickremasinghe H, Jiang X, Hu Y, Du H, Zhu Y, Velkov T. Lu J, et al. Microbiol Spectr. 2023 Aug 17;11(4):e0085223. doi: 10.1128/spectrum.00852-23. Epub 2023 Jul 11. Microbiol Spectr. 2023. PMID: 37432123 Free PMC article.

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