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A positive feedback loop controls Toxoplasma chronic differentiation.
Licon MH, Giuliano CJ, Chan AW, Chakladar S, Eberhard JN, Shallberg LA, Chandrasekaran S, Waldman BS, Koshy AA, Hunter CA, Lourido S. Licon MH, et al. Nat Microbiol. 2023 May;8(5):889-904. doi: 10.1038/s41564-023-01358-2. Epub 2023 Apr 20. Nat Microbiol. 2023. PMID: 37081202 Free PMC article.
Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8+ T cell responses.
Haskins BE, Gullicksrud JA, Wallbank BA, Dumaine JE, Guérin A, Cohn IS, O'Dea KM, Pardy RD, Merolle MI, Shallberg LA, Hunter EN, Byerly JH, Smith EJ, Buenconsejo GY, McLeod BI, Christian DA, Striepen B, Hunter CA. Haskins BE, et al. Mucosal Immunol. 2024 Jun;17(3):387-401. doi: 10.1016/j.mucimm.2024.03.003. Epub 2024 Mar 18. Mucosal Immunol. 2024. PMID: 38508522 Free PMC article.
Intestinal cDC1s provide IL-12 dependent and independent functions required for CD4+ T cell-mediated resistance to Cryptosporidium.
Cohn IS, Wallbank BA, Haskins BE, O'Dea KM, Pardy RD, Shaw S, Merolle MI, Gullicksrud JA, Christian DA, Striepen B, Hunter CA. Cohn IS, et al. bioRxiv [Preprint]. 2023 Nov 13:2023.11.11.566669. doi: 10.1101/2023.11.11.566669. bioRxiv. 2023. Update in: J Exp Med. 2024 Jul 1;221(7):e20232067. doi: 10.1084/jem.20232067 PMID: 38014026 Free PMC article. Updated. Preprint.