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Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
Martinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Zihsler S, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF. Martinez HA, et al. Nat Commun. 2024 Feb 20;15(1):1564. doi: 10.1038/s41467-024-45012-9. Nat Commun. 2024. PMID: 38378682 Free PMC article.
FOXP3+ regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues.
Martinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF. Martinez HA, et al. bioRxiv [Preprint]. 2023 Feb 27:2023.02.26.529772. doi: 10.1101/2023.02.26.529772. bioRxiv. 2023. Update in: Nat Commun. 2024 Feb 20;15(1):1564. doi: 10.1038/s41467-024-45012-9 PMID: 36909599 Free PMC article. Updated. Preprint.
Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint.
Pieper J, Dubnovitsky A, Gerstner C, James EA, Rieck M, Kozhukh G, Tandre K, Pellegrino S, Gebe JA, Rönnblom L, Sandalova T, Kwok WW, Klareskog L, Buckner JH, Achour A, Malmström V. Pieper J, et al. J Autoimmun. 2018 Aug;92:47-56. doi: 10.1016/j.jaut.2018.04.004. Epub 2018 May 28. J Autoimmun. 2018. PMID: 29853344 Free PMC article.
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