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Page 1
Drug discovery for heart failure targeting myosin-binding protein C.
Bunch TA, Guhathakurta P, Thompson AR, Lepak VC, Carter AL, Thomas JJ, Thomas DD, Colson BA. Bunch TA, et al. J Biol Chem. 2023 Dec;299(12):105369. doi: 10.1016/j.jbc.2023.105369. Epub 2023 Oct 20. J Biol Chem. 2023. PMID: 37865311 Free PMC article.
Hypertrophic cardiomyopathy in MYBPC3 carriers in aging.
Ananthamohan K, Stelzer JE, Sadayappan S. Ananthamohan K, et al. J Cardiovasc Aging. 2024 Jan;4(1):9. doi: 10.20517/jca.2023.29. Epub 2024 Jan 11. J Cardiovasc Aging. 2024. PMID: 38406555 Free PMC article.
Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function.
Landim-Vieira M, Ma W, Song T, Rastegarpouyani H, Gong H, Coscarella IL, Bogaards SJP, Conijn SP, Ottenheijm CAC, Hwang HS, Papadaki M, Knollmann BC, Sadayappan S, Irving TC, Galkin VE, Chase PB, Pinto JR. Landim-Vieira M, et al. Proc Natl Acad Sci U S A. 2023 Jun 6;120(23):e2221244120. doi: 10.1073/pnas.2221244120. Epub 2023 May 30. Proc Natl Acad Sci U S A. 2023. PMID: 37252999 Free PMC article.
Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure.
Hessel AL, Kuehn M, Han SW, Ma W, Irving TC, Momb BA, Song T, Sadayappan S, Linke WA, Palmer BM. Hessel AL, et al. bioRxiv [Preprint]. 2023 Oct 23:2023.10.19.563160. doi: 10.1101/2023.10.19.563160. bioRxiv. 2023. Update in: Commun Biol. 2024 May 27;7(1):648. doi: 10.1038/s42003-024-06265-8 PMID: 37961718 Free PMC article. Updated. Preprint.
A Multi-Omics Approach to Defining Target Organ Injury in Youth with Primary Hypertension.
Ananthamohan K, Brady TM, Arif M, Daniels S, Falkner B, Ferguson M, Flynn JT, Hanevold C, Hooper SR, Ingelfinger J, Lande M, Martin LJ, Meyers KE, Mitsnefes M, Rosner B, Samuels JA, Kuffel G, Zilliox MJ, Becker RC, Urbina EM, Sadayappan S. Ananthamohan K, et al. bioRxiv [Preprint]. 2024 Jun 18:2024.06.17.599125. doi: 10.1101/2024.06.17.599125. bioRxiv. 2024. PMID: 38948714 Free PMC article. Preprint.
Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction in db/db mice.
Desai DA, Baby A, Ananthamohan K, Green LC, Arif M, Duncan BC, Kumar M, Singh RR, Koch SE, Natesan S, Rubinstein J, Jegga AG, Sadayappan S. Desai DA, et al. J Mol Cell Cardiol Plus. 2024 Jun;8:100075. doi: 10.1016/j.jmccpl.2024.100075. Epub 2024 Apr 4. J Mol Cell Cardiol Plus. 2024. PMID: 38957358 Free PMC article.