R01 CA089346/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2005	2
2006	1
2007	3
2008	2
2010	1
2024	0

1

MEK blockade converts AML differentiating response to retinoids into extensive apoptosis.

Milella M, Konopleva M, Precupanu CM, Tabe Y, Ricciardi MR, Gregorj C, Collins SJ, Carter BZ, D'Angelo C, Petrucci MT, Foà R, Cognetti F, Tafuri A, Andreeff M. Milella M, et al. Blood. 2007 Mar 1;109(5):2121-9. doi: 10.1182/blood-2006-05-024679. Epub 2006 Oct 31. Blood. 2007. PMID: 17077328 Free article.

2

2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer.

Samudio I, Konopleva M, Hail N Jr, Shi YX, McQueen T, Hsu T, Evans R, Honda T, Gribble GW, Sporn M, Gilbert HF, Safe S, Andreeff M. Samudio I, et al. J Biol Chem. 2005 Oct 28;280(43):36273-82. doi: 10.1074/jbc.M507518200. Epub 2005 Aug 23. J Biol Chem. 2005. PMID: 16118208 Free article.

3

Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia.

Kojima K, Konopleva M, Tsao T, Nakakuma H, Andreeff M. Kojima K, et al. Blood. 2008 Oct 1;112(7):2886-95. doi: 10.1182/blood-2008-01-128611. Epub 2008 Jul 16. Blood. 2008. PMID: 18633130 Free PMC article.

4

Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells.

Samudio I, Kurinna S, Ruvolo P, Korchin B, Kantarjian H, Beran M, Dunner K Jr, Kondo S, Andreeff M, Konopleva M. Samudio I, et al. Mol Cancer Ther. 2008 May;7(5):1130-9. doi: 10.1158/1535-7163.MCT-07-0553. Mol Cancer Ther. 2008. PMID: 18483301 Free PMC article.

5

Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma.

Kress CL, Konopleva M, Martínez-García V, Krajewska M, Lefebvre S, Hyer ML, McQueen T, Andreeff M, Reed JC, Zapata JM. Kress CL, et al. PLoS One. 2007 Jun 27;2(6):e559. doi: 10.1371/journal.pone.0000559. PLoS One. 2007. PMID: 17593960 Free PMC article.

6

The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells.

Konopleva M, Contractor R, Kurinna SM, Chen W, Andreeff M, Ruvolo PP. Konopleva M, et al. Leukemia. 2005 Aug;19(8):1350-4. doi: 10.1038/sj.leu.2403828. Leukemia. 2005. PMID: 15931262

7

CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha.

Koschmieder S, D'Alò F, Radomska H, Schöneich C, Chang JS, Konopleva M, Kobayashi S, Levantini E, Suh N, Di Ruscio A, Voso MT, Watt JC, Santhanam R, Sargin B, Kantarjian H, Andreeff M, Sporn MB, Perrotti D, Berdel WE, Müller-Tidow C, Serve H, Tenen DG. Koschmieder S, et al. Blood. 2007 Nov 15;110(10):3695-705. doi: 10.1182/blood-2006-11-058941. Epub 2007 Aug 1. Blood. 2007. PMID: 17671235 Free PMC article. Clinical Trial.

8

The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias.

Kojima K, Burks JK, Arts J, Andreeff M. Kojima K, et al. Mol Cancer Ther. 2010 Sep;9(9):2545-57. doi: 10.1158/1535-7163.MCT-10-0337. Epub 2010 Aug 24. Mol Cancer Ther. 2010. PMID: 20736344 Free PMC article.

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