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Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer.
Abril YLN, Fernandez IR, Hong JY, Chiang YL, Kutateladze DA, Zhao Q, Yang M, Hu J, Sadhukhan S, Li B, He B, Remick B, Bai JJ, Mullmann J, Wang F, Maymi V, Dhawan R, Auwerx J, Southard T, Cerione RA, Lin H, Weiss RS. Abril YLN, et al. Oncogene. 2021 Mar;40(9):1644-1658. doi: 10.1038/s41388-020-01637-w. Epub 2021 Jan 21. Oncogene. 2021. PMID: 33479498 Free PMC article.
SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis.
Greene KS, Lukey MJ, Wang X, Blank B, Druso JE, Lin MJ, Stalnecker CA, Zhang C, Negrón Abril Y, Erickson JW, Wilson KF, Lin H, Weiss RS, Cerione RA. Greene KS, et al. Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26625-26632. doi: 10.1073/pnas.1911954116. Epub 2019 Dec 16. Proc Natl Acad Sci U S A. 2019. PMID: 31843902 Free PMC article.
13 results