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Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel.
Scribano CM, Wan J, Esbona K, Tucker JB, Lasek A, Zhou AS, Zasadil LM, Molini R, Fitzgerald J, Lager AM, Laffin JJ, Correia-Staudt K, Wisinski KB, Tevaarwerk AJ, O'Regan R, McGregor SM, Fowler AM, Chappell RJ, Bugni TS, Burkard ME, Weaver BA. Scribano CM, et al. Sci Transl Med. 2021 Sep 8;13(610):eabd4811. doi: 10.1126/scitranslmed.abd4811. Epub 2021 Sep 8. Sci Transl Med. 2021. PMID: 34516829 Free PMC article.
Chromosomal instability upregulates interferon in acute myeloid leukemia.
Jin N, Lera RF, Yan RE, Guo F, Oxendine K, Horner VL, Hu Y, Wan J, Mattison RJ, Weaver BA, Burkard ME. Jin N, et al. Genes Chromosomes Cancer. 2020 Nov;59(11):627-638. doi: 10.1002/gcc.22880. Epub 2020 Jul 18. Genes Chromosomes Cancer. 2020. PMID: 32557940 Free PMC article.
HPV16 E6 induces chromosomal instability due to polar chromosomes caused by E6AP-dependent degradation of the mitotic kinesin CENP-E.
Cosper PF, Hrycyniak LCF, Paracha M, Lee DL, Wan J, Jones K, Bice SA, Nickel K, Mallick S, Taylor AM, Kimple RJ, Lambert PF, Weaver BA. Cosper PF, et al. Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2216700120. doi: 10.1073/pnas.2216700120. Epub 2023 Mar 29. Proc Natl Acad Sci U S A. 2023. PMID: 36989302 Free PMC article.
Classes of therapeutics to amplify the immune response.
Hu Y, Burkard ME. Hu Y, et al. Breast Cancer Res Treat. 2022 Jan;191(2):277-289. doi: 10.1007/s10549-021-06369-3. Epub 2021 Nov 17. Breast Cancer Res Treat. 2022. PMID: 34787761 Review.
A survey of chromosomal instability measures across mechanistic models.
Lynch AR, Bradford S, Zhou AS, Oxendine K, Henderson L, Horner VL, Weaver BA, Burkard ME. Lynch AR, et al. Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2309621121. doi: 10.1073/pnas.2309621121. Epub 2024 Apr 8. Proc Natl Acad Sci U S A. 2024. PMID: 38588415 Free PMC article.
24 results