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Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment.
He XY, Gao Y, Ng D, Michalopoulou E, George S, Adrover JM, Sun L, Albrengues J, Daßler-Plenker J, Han X, Wan L, Wu XS, Shui LS, Huang YH, Liu B, Su C, Spector DL, Vakoc CR, Van Aelst L, Egeblad M. He XY, et al. Cancer Cell. 2024 Mar 11;42(3):474-486.e12. doi: 10.1016/j.ccell.2024.01.013. Epub 2024 Feb 22. Cancer Cell. 2024. PMID: 38402610
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants.
Hirschhorn D, Budhu S, Kraehenbuehl L, Gigoux M, Schröder D, Chow A, Ricca JM, Gasmi B, De Henau O, Mangarin LMB, Li Y, Hamadene L, Flamar AL, Choi H, Cortez CA, Liu C, Holland A, Schad S, Schulze I, Betof Warner A, Hollmann TJ, Arora A, Panageas KS, Rizzuto GA, Duhen R, Weinberg AD, Spencer CN, Ng D, He XY, Albrengues J, Redmond D, Egeblad M, Wolchok JD, Merghoub T. Hirschhorn D, et al. Cell. 2023 Mar 30;186(7):1432-1447.e17. doi: 10.1016/j.cell.2023.03.007. Cell. 2023. PMID: 37001503 Free PMC article.
Innate Immunity and Cancer Pathophysiology.
Maiorino L, Daßler-Plenker J, Sun L, Egeblad M. Maiorino L, et al. Annu Rev Pathol. 2022 Jan 24;17:425-457. doi: 10.1146/annurev-pathmechdis-032221-115501. Epub 2021 Nov 17. Annu Rev Pathol. 2022. PMID: 34788549 Free PMC article. Review.
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity.
Chen HA, Ho YJ, Mezzadra R, Adrover JM, Smolkin R, Zhu C, Woess K, Bernstein N, Schmitt G, Fong L, Luan W, Wuest A, Tian S, Li X, Broderick C, Hendrickson RC, Egeblad M, Chen Z, Alonso-Curbelo D, Lowe SW. Chen HA, et al. Cancer Discov. 2023 Feb 6;13(2):432-453. doi: 10.1158/2159-8290.CD-22-0528. Cancer Discov. 2023. PMID: 36302222 Free PMC article.
Longitudinal Intravital Imaging Through Clear Silicone Windows.
Maiorino L, Shevik M, Adrover JM, Han X, Georgas E, Wilkinson JE, Seidner H, Foerschner L, Tuveson DA, Qin YX, Egeblad M. Maiorino L, et al. J Vis Exp. 2022 Jan 5;(179):10.3791/62757. doi: 10.3791/62757. J Vis Exp. 2022. PMID: 35068483 Free PMC article.