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An aged immune system drives senescence and ageing of solid organs.
Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, Cui Y, Angelini L, Lee KA, McGowan SJ, Burrack AL, Wang D, Dong Q, Lu A, Sano T, O'Kelly RD, McGuckian CA, Kato JI, Bank MP, Wade EA, Pillai SPS, Klug J, Ladiges WC, Burd CE, Lewis SE, LaRusso NF, Vo NV, Wang Y, Kelley EE, Huard J, Stromnes IM, Robbins PD, Niedernhofer LJ. Yousefzadeh MJ, et al. Nature. 2021 Jun;594(7861):100-105. doi: 10.1038/s41586-021-03547-7. Epub 2021 May 12. Nature. 2021. PMID: 33981041 Free PMC article.
Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma.
Patterson MT, Burrack AL, Xu Y, Hickok GH, Schmiechen ZC, Becker S, Cruz-Hinojoza E, Schrank PR, Kennedy AE, Firulyova MM, Miller EA, Zaitsev K, Williams JW, Stromnes IM. Patterson MT, et al. Cell Rep. 2023 Jul 25;42(7):112732. doi: 10.1016/j.celrep.2023.112732. Epub 2023 Jul 3. Cell Rep. 2023. PMID: 37402168 Free PMC article.
Cxcr3 constrains pancreatic cancer dissemination through instructing T cell fate.
Burrack AL, Spartz EJ, Rollins MR, Miller EA, Firulyova M, Cruz E, Goldberg MF, Wang IX, Nanda H, Shen S, Zaitsev K, Stromnes IM. Burrack AL, et al. Cancer Immunol Immunother. 2023 Jun;72(6):1461-1478. doi: 10.1007/s00262-022-03338-7. Epub 2022 Dec 6. Cancer Immunol Immunother. 2023. PMID: 36472588 Free PMC article.