Abstract
We report a case of Candida glabrata invasive candidiasis that developed reduced susceptibility to caspofungin during prolonged therapy. Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution within the FKS2 region of the glucan synthase complex.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
MeSH terms
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Adult
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Amino Acid Substitution
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Antifungal Agents / pharmacology*
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Base Sequence
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Candida glabrata / drug effects*
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Candida glabrata / enzymology
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Candida glabrata / genetics
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Candidiasis / drug therapy*
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Candidiasis / microbiology*
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Caspofungin
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DNA Primers / genetics
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DNA, Fungal / genetics
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Drug Resistance, Fungal / genetics
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Echinocandins / pharmacology*
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Genes, Fungal
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Glucosyltransferases / genetics
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Humans
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Lipopeptides
Substances
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Antifungal Agents
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DNA Primers
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DNA, Fungal
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Echinocandins
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Lipopeptides
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Glucosyltransferases
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glucan synthase
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Caspofungin