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Page 1
WNK kinases sense molecular crowding and rescue cell volume via phase separation.
Boyd-Shiwarski CR, Shiwarski DJ, Griffiths SE, Beacham RT, Norrell L, Morrison DE, Wang J, Mann J, Tennant W, Anderson EN, Franks J, Calderon M, Connolly KA, Cheema MU, Weaver CJ, Nkashama LJ, Weckerly CC, Querry KE, Pandey UB, Donnelly CJ, Sun D, Rodan AR, Subramanya AR. Boyd-Shiwarski CR, et al. Cell. 2022 Nov 23;185(24):4488-4506.e20. doi: 10.1016/j.cell.2022.09.042. Epub 2022 Oct 31. Cell. 2022. PMID: 36318922 Free PMC article.
Emerging Targets of Diuretic Therapy.
Cheng CJ, Rodan AR, Huang CL. Cheng CJ, et al. Clin Pharmacol Ther. 2017 Sep;102(3):420-435. doi: 10.1002/cpt.754. Epub 2017 Jul 10. Clin Pharmacol Ther. 2017. PMID: 28560800 Free PMC article. Review.
Intracellular Ion Control of WNK Signaling.
Goldsmith EJ, Rodan AR. Goldsmith EJ, et al. Annu Rev Physiol. 2023 Feb 10;85:383-406. doi: 10.1146/annurev-physiol-031522-080651. Epub 2022 Oct 13. Annu Rev Physiol. 2023. PMID: 36228173 Free article. Review.
Osmosensing by WNK Kinases.
Akella R, Humphreys JM, Sekulski K, He H, Durbacz M, Chakravarthy S, Liwocha J, Mohammed ZJ, Brautigam CA, Goldsmith EJ. Akella R, et al. Mol Biol Cell. 2021 Aug 19;32(18):1614-1623. doi: 10.1091/mbc.E20-01-0089. Epub 2021 Mar 10. Mol Biol Cell. 2021. PMID: 33689398 Free PMC article.
WNKs are potassium-sensitive kinases.
Pleinis JM, Norrell L, Akella R, Humphreys JM, He H, Sun Q, Zhang F, Sosa-Pagan J, Morrison DE, Schellinger JN, Jackson LK, Goldsmith EJ, Rodan AR. Pleinis JM, et al. Am J Physiol Cell Physiol. 2021 May 1;320(5):C703-C721. doi: 10.1152/ajpcell.00456.2020. Epub 2021 Jan 13. Am J Physiol Cell Physiol. 2021. PMID: 33439774 Free PMC article.
Hydrostatic Pressure Sensing by WNK kinases.
Humphreys JM, Teixeira LR, Akella R, He H, Kannangara AR, Sekulski K, Pleinis J, Liwocha J, Jiou J, Servage KA, Orth K, Joachimiak L, Rizo J, Cobb MH, Brautigam CA, Rodan AR, Goldsmith EJ. Humphreys JM, et al. Mol Biol Cell. 2023 Oct 1;34(11):ar109. doi: 10.1091/mbc.E23-03-0113. Epub 2023 Aug 16. Mol Biol Cell. 2023. PMID: 37585288 Free PMC article.
43 results