R01 DK116352/DK/NIDDK NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2019	1
2020	7
2021	2
2022	3
2023	4
2024	0

1

Has a physiologic function for NHE2 finally been identified?

Donowitz M. Donowitz M. Acta Physiol (Oxf). 2022 Mar;234(3):e13792. doi: 10.1111/apha.13792. Epub 2022 Feb 11. Acta Physiol (Oxf). 2022. PMID: 35094506 Free PMC article. No abstract available.

2

Current and potential future applications of human stem cell models in drug development.

Donowitz M, Turner JR, Verkman AS, Zachos NC. Donowitz M, et al. J Clin Invest. 2020 Jul 1;130(7):3342-3344. doi: 10.1172/JCI138645. J Clin Invest. 2020. PMID: 32452833 Free PMC article. Review. No abstract available.

3

A Novel Peptide Prevents Enterotoxin- and Inflammation-Induced Intestinal Fluid Secretion by Stimulating Sodium-Hydrogen Exchanger 3 Activity.

Zachos NC, Vaughan H, Sarker R, Est-Witte S, Chakraborty M, Baetz NW, Yu H, Yarov-Yarovoy V, McNamara G, Green JJ, Tse CM, Donowitz M. Zachos NC, et al. Gastroenterology. 2023 Oct;165(4):986-998.e11. doi: 10.1053/j.gastro.2023.06.028. Epub 2023 Jul 8. Gastroenterology. 2023. PMID: 37429363 Free PMC article.

4

Chronic Inflammation in Ulcerative Colitis Causes Long-Term Changes in Goblet Cell Function.

Singh V, Johnson K, Yin J, Lee S, Lin R, Yu H, In J, Foulke-Abel J, Zachos NC, Donowitz M, Rong Y. Singh V, et al. Cell Mol Gastroenterol Hepatol. 2022;13(1):219-232. doi: 10.1016/j.jcmgh.2021.08.010. Epub 2021 Aug 18. Cell Mol Gastroenterol Hepatol. 2022. PMID: 34418586 Free PMC article.

5

Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip.

Yin J, Sunuwar L, Kasendra M, Yu H, Tse CM, Talbot CC Jr, Boronina T, Cole R, Karalis K, Donowitz M. Yin J, et al. Am J Physiol Gastrointest Liver Physiol. 2021 Mar 1;320(3):G258-G271. doi: 10.1152/ajpgi.00282.2020. Epub 2020 Oct 14. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 33074011 Free PMC article.

6

Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection.

Foulke-Abel J, Yu H, Sunuwar L, Lin R, Fleckenstein JM, Kaper JB, Donowitz M. Foulke-Abel J, et al. Gut Microbes. 2020 Nov 9;12(1):1752125. doi: 10.1080/19490976.2020.1752125. Epub 2020 May 7. Gut Microbes. 2020. PMID: 32378997 Free PMC article.

7

Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2.

Smyth JS, Truong JK, Rao A, Lin R, Foulke-Abel J, Adorini L, Donowitz M, Dawson PA, Keely SJ. Smyth JS, et al. Am J Physiol Gastrointest Liver Physiol. 2023 Nov 1;325(5):G446-G452. doi: 10.1152/ajpgi.00099.2023. Epub 2023 Sep 12. Am J Physiol Gastrointest Liver Physiol. 2023. PMID: 37697930 Free PMC article.

8

Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model.

Kasendra M, Luc R, Yin J, Manatakis DV, Kulkarni G, Lucchesi C, Sliz J, Apostolou A, Sunuwar L, Obrigewitch J, Jang KJ, Hamilton GA, Donowitz M, Karalis K. Kasendra M, et al. Elife. 2020 Jan 14;9:e50135. doi: 10.7554/eLife.50135. Elife. 2020. PMID: 31933478 Free PMC article.

9

Cholinergic-induced anion secretion in murine jejunal enteroids involves synergy between muscarinic and nicotinic pathways.

Johnson K, Yin J, In JG, Kulkarni S, Pasricha P, Tse CM, Donowitz M. Johnson K, et al. Am J Physiol Cell Physiol. 2020 Aug 1;319(2):C321-C330. doi: 10.1152/ajpcell.00179.2020. Epub 2020 Jun 17. Am J Physiol Cell Physiol. 2020. PMID: 32551856 Free PMC article.

10

SLC26A3 (DRA) is stimulated in a synergistic, intracellular Ca²⁺-dependent manner by cAMP and ATP in intestinal epithelial cells.

Sarker R, Lin R, Singh V, Donowitz M, Tse CM. Sarker R, et al. Am J Physiol Cell Physiol. 2023 Jun 1;324(6):C1263-C1273. doi: 10.1152/ajpcell.00523.2022. Epub 2023 May 8. Am J Physiol Cell Physiol. 2023. PMID: 37154494 Free PMC article.

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