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Page 1
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise.
Klein AB, Nicolaisen TS, Ørtenblad N, Gejl KD, Jensen R, Fritzen AM, Larsen EL, Karstoft K, Poulsen HE, Morville T, Sahl RE, Helge JW, Lund J, Falk S, Lyngbæk M, Ellingsgaard H, Pedersen BK, Lu W, Finan B, Jørgensen SB, Seeley RJ, Kleinert M, Kiens B, Richter EA, Clemmensen C. Klein AB, et al. Nat Commun. 2021 Feb 15;12(1):1041. doi: 10.1038/s41467-021-21309-x. Nat Commun. 2021. PMID: 33589633 Free PMC article.
Leveraging the Gut to Treat Metabolic Disease.
Gimeno RE, Briere DA, Seeley RJ. Gimeno RE, et al. Cell Metab. 2020 Apr 7;31(4):679-698. doi: 10.1016/j.cmet.2020.02.014. Epub 2020 Mar 17. Cell Metab. 2020. PMID: 32187525 Free PMC article. Review.
GFRAL-expressing neurons suppress food intake via aversive pathways.
Sabatini PV, Frikke-Schmidt H, Arthurs J, Gordian D, Patel A, Rupp AC, Adams JM, Wang J, Beck Jørgensen S, Olson DP, Palmiter RD, Myers MG Jr, Seeley RJ. Sabatini PV, et al. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2021357118. doi: 10.1073/pnas.2021357118. Proc Natl Acad Sci U S A. 2021. PMID: 33593916 Free PMC article.
Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation.
Breen DM, Jagarlapudi S, Patel A, Zou C, Joaquim S, Li X, Kang L, Pang J, Hales K, Ziso-Qejvanaj E, Vera NB, Bennett D, He T, Lambert M, Kelleher K, Wu Z, Zhang BB, Lin L, Seeley RJ, Bezy O. Breen DM, et al. iScience. 2021 May 19;24(6):102554. doi: 10.1016/j.isci.2021.102554. eCollection 2021 Jun 25. iScience. 2021. PMID: 34189431 Free PMC article.
Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.
Cheng W, Gonzalez I, Pan W, Tsang AH, Adams J, Ndoka E, Gordian D, Khoury B, Roelofs K, Evers SS, MacKinnon A, Wu S, Frikke-Schmidt H, Flak JN, Trevaskis JL, Rhodes CJ, Fukada SI, Seeley RJ, Sandoval DA, Olson DP, Blouet C, Myers MG Jr. Cheng W, et al. Cell Metab. 2020 Feb 4;31(2):301-312.e5. doi: 10.1016/j.cmet.2019.12.012. Epub 2020 Jan 16. Cell Metab. 2020. PMID: 31955990 Free PMC article.
15 results