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Page 1
Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.
Sun Y, Rahbani JF, Jedrychowski MP, Riley CL, Vidoni S, Bogoslavski D, Hu B, Dumesic PA, Zeng X, Wang AB, Knudsen NH, Kim CR, Marasciullo A, Millán JL, Chouchani ET, Kazak L, Spiegelman BM. Sun Y, et al. Nature. 2021 May;593(7860):580-585. doi: 10.1038/s41586-021-03533-z. Epub 2021 May 12. Nature. 2021. PMID: 33981039 Free PMC article.
Creatine kinase B controls futile creatine cycling in thermogenic fat.
Rahbani JF, Roesler A, Hussain MF, Samborska B, Dykstra CB, Tsai L, Jedrychowski MP, Vergnes L, Reue K, Spiegelman BM, Kazak L. Rahbani JF, et al. Nature. 2021 Feb;590(7846):480-485. doi: 10.1038/s41586-021-03221-y. Epub 2021 Feb 17. Nature. 2021. PMID: 33597756 Free PMC article.
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues.
Mittenbühler MJ, Jedrychowski MP, Van Vranken JG, Sprenger HG, Wilensky S, Dumesic PA, Sun Y, Tartaglia A, Bogoslavski D, A M, Xiao H, Blackmore KA, Reddy A, Gygi SP, Chouchani ET, Spiegelman BM. Mittenbühler MJ, et al. Cell Metab. 2023 Mar 7;35(3):535-549.e7. doi: 10.1016/j.cmet.2022.12.014. Epub 2023 Jan 20. Cell Metab. 2023. PMID: 36681077 Free PMC article.
Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.
Mills EL, Harmon C, Jedrychowski MP, Xiao H, Gruszczyk AV, Bradshaw GA, Tran N, Garrity R, Laznik-Bogoslavski D, Szpyt J, Prendeville H, Lynch L, Murphy MP, Gygi SP, Spiegelman BM, Chouchani ET. Mills EL, et al. Cell Metab. 2022 Jan 4;34(1):140-157.e8. doi: 10.1016/j.cmet.2021.11.003. Epub 2021 Dec 2. Cell Metab. 2022. PMID: 34861155 Free PMC article.
Mechanism of futile creatine cycling in thermogenesis.
Kazak L, Spiegelman BM. Kazak L, et al. Am J Physiol Endocrinol Metab. 2020 Nov 1;319(5):E947-E949. doi: 10.1152/ajpendo.00444.2020. Epub 2020 Sep 21. Am J Physiol Endocrinol Metab. 2020. PMID: 32954828 Free article. No abstract available.
REPTOR and CREBRF encode key regulators of muscle energy metabolism.
Saavedra P, Dumesic PA, Hu Y, Filine E, Jouandin P, Binari R, Wilensky SE, Rodiger J, Wang H, Chen W, Liu Y, Spiegelman BM, Perrimon N. Saavedra P, et al. Nat Commun. 2023 Aug 15;14(1):4943. doi: 10.1038/s41467-023-40595-1. Nat Commun. 2023. PMID: 37582831 Free PMC article.
Measurement of Futile Creatine Cycling Using Respirometry.
Rahbani JF, Chouchani ET, Spiegelman BM, Kazak L. Rahbani JF, et al. Methods Mol Biol. 2022;2448:141-153. doi: 10.1007/978-1-0716-2087-8_10. Methods Mol Biol. 2022. PMID: 35167096 Free PMC article.