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Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation.
Liu TC, Kern JT, Jain U, Sonnek NM, Xiong S, Simpson KF, VanDussen KL, Winkler ES, Haritunians T, Malique A, Lu Q, Sasaki Y, Storer C, Diamond MS, Head RD, McGovern DPB, Stappenbeck TS. Liu TC, et al. Cell Host Microbe. 2021 Jun 9;29(6):988-1001.e6. doi: 10.1016/j.chom.2021.04.004. Epub 2021 May 18. Cell Host Microbe. 2021. PMID: 34010595 Free PMC article.
Infection and inflammation stimulate expansion of a CD74+ Paneth cell subset to regulate disease progression.
Balasubramanian I, Bandyopadhyay S, Flores J, Bianchi-Smak J, Lin X, Liu H, Sun S, Golovchenko NB, Liu Y, Wang D, Patel R, Joseph I, Suntornsaratoon P, Vargas J, Green PH, Bhagat G, Lagana SM, Ying W, Zhang Y, Wang Z, Li WV, Singh S, Zhou Z, Kollias G, Farr LA, Moonah SN, Yu S, Wei Z, Bonder EM, Zhang L, Kiela PR, Edelblum KL, Ferraris R, Liu TC, Gao N. Balasubramanian I, et al. EMBO J. 2023 Nov 2;42(21):e113975. doi: 10.15252/embj.2023113975. Epub 2023 Sep 18. EMBO J. 2023. PMID: 37718683 Free PMC article.